Studies on the primary sequence requirements for PKC-α, -β1and -γ peptide substrates

Studies on the specificity of phosphorylase kinase using peptide substrates.

The action of phosphorylase kinase on synthetic peptides is reported. These peptides are variants of the amino acid sequence. Ser-Asp-Gln-Glu-Lys-Arg-Lys-Gln-Ile-Ser-Val-Arg-Gly-Leu, found in the natural substrate, phosphorylase b. The effects of size, the cluster of basic groups at the NH2-terminal side, the phosphorylatable seryl residue, the hydrophobic groups surrounding serine, and the arg...

On the Rational Recursive Sequence xn+1=(α-βxn)/(γ-δxn-xn-k)

We study the global stability, the periodic character, and the boundedness character of the positive solutions of the difference equation xn 1 α − βxn / γ − δxn − xn−k , n 0, 1, 2, . . . , k ∈ {1, 2, . . .}, in the two cases: i δ ≥ 0, α > 0, γ > β > 0; ii δ ≥ 0, α 0, γ, β > 0, where the coefficients α, β, γ, and δ, and the initial conditions x−k, x−k 1, . . . , x−1, x0 are real numbers. We show...

Omegatides: constrained analogs of peptide primary sequence.

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

The JmjC-domain-containing 2-oxoglutarate-dependent oxygenases catalyze protein hydroxylation and N(ϵ)-methyllysine demethylation via hydroxylation. A subgroup of this family, the JmjC lysine demethylases (JmjC KDMs) are involved in histone modifications at multiple sites. There are conflicting reports as to the substrate selectivity of some JmjC oxygenases with respect to KDM activities. In th...

“the effect of risk aversion on the demand for life insurance: the case of iranian life insurance market”

abstract: about 60% of total premium of insurance industry is pertained?to life policies in the world; while the life insurance total premium in iran is less than 6% of total premium in insurance industry in 2008 (sigma, no 3/2009). among the reasons that discourage the life insurance industry is the problem of adverse selection. adverse selection theory describes a situation where the inf...